30/01/2017 - LNC - Laure Verret (CNRS/Université Paul Sabatier, Toulouse)

Laure Verret (CNRS/Université Paul Sabatier, Toulouse)

Social Memory Impairments and Area CA2 Modifications in a Mouse Model of Alzheimer’s Disease

Among the cognitive impairments observed in Alzheimer’s disease (AD) patients, one of the most excruciating is their inability to recognize or remember other people. Distressingly, social memory and recognition have been barely investigated in AD mouse models, and little is known about the neural substrates of social memory impairments in AD. Very recently, it has been demonstrated that inactivation of area CA2 pyramidal neurons induces specific social memory impairments (Hitti & Siegelbaum 2014), and this hippocampal structure is now considered as a critical hub for sociocognitive memory processing (Chevaleyre & Piskorowski 2016). Thus, we hypothesized that social memory impairments in AD mouse models could be mediated by area CA2 dysfunction. We observed anatomical modifications in the area CA2 of AD mice, which are inducing decreased inhibitory control of CA2 pyramidal cells, and are associated with social recognition and social memory impairments. We are now exploring whether there is a causal link between these anatomical alterations in area CA2 and social memory deficits in the context of AD.

30/01/2017 à 13:30